Utility of azalactones in synthesis of some new heterocyclic compounds
نویسنده
چکیده
Azalactone 1 can be synthesized via treatment of 4chlorobenzoyl glycine with p-anisaldehyde in the presence of acetic anhydride and sod Acetate. The behaviour of azalactone 1 towards nitrogen nucleophiles, for example, anthranilic acid, 6-aminopyrimidin-2,4-dione and 2-amino-6-phenyl 1,3,4thiadiazole can be investigated. Benzoxazone 2 can be treated with hydrazine hydrate, hydroxylamine hydrochloride, and o-phenylenediamine in different reaction conditions to afford quinazolinone derivatives 3, 4, 5, 6. The imidazoloquinazolinone derivative 6 can be treated with hydrazine derivatives. Pyrimidino/thiadiazolopyrimidine 8, 11 can be treated with acetic anhydride to increase their biological activities. The structures of all synthesized compounds were confirmed from analytical as well as spectral data.
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